The defects in medicine packaging design for the elderly were targeted, such as the difficulty in opening, the difficulty in reading the medicine information and the difficulty in controling the medicine dosage. Based on the principles of ergonomics, the medicine packaging design optimization for elderly should be conducted in the aspects of packaging opening mode, decoration design of medicine, and structure design. Therefore, the optimized packaging of portable medicine bottle and detachable medicine bottle were designed, and the internal packaging and decoration of them were optimized. The reasonability and feasibility of the optimized designs were verified through transporation design experiment of the two medicine bottles, which reflected the design concept of integrated product and packaging and met the psychological and physiological needs of the elderly.