Under the guidance of major strategies of national innovation-driven development, made in China 2025 and innovation-originated nation building, the technological innovation capacity of printing and packaging enterprises in Hunan province has been enhanced. However, these enterprises are still inadequate in the aspects of science and technology innovation qualification, R&D investment, patent technology, research and development institutions, government science and technology projects, and science and technology innovation awards. Therefore, packaging and printing enterprises have to increase R&D investment to grasp the core technology in the direction of green, intelligent development in order to remain invincible in the intense, complex and changeable market environment.