Two kinds of spectrophotometers were selected and the color difference was taken as the evaluation index to explore the overall rule of color measurement of glazed tile by spectrophotometer under different measurement parameters. The results showed that the measurement results were stable under fixed measurement aperture in SCI and SCE measurement modes, but different measurement apertures had significant influence on the measurement results. Under the measurement conditions recommended by CIE, the color difference stability of SCI and 45°/0°was better than that of SCE and 45°/0°in different measurement apertures. However, the color difference of SCI and 45°/0° was significantly greater than that of SCE and 45°/0°and the color difference of SCE at 10mm measurement aperture was close to 45°/0°measurement result. The greater the curvature of the glazed tile, the less stable the measurement results of different measuring modes were. The results of measurement with large aperture (10 mm) showed the most obvious difference. SCE was more sensitive to surface morphology changes of glazed tiles comparing with SCI and 45°/0°. In general, the SCE measurement mode of integrating sphere spectrophotometer was more suitable for the color measurement of glazed tile, and the larger size measurement aperture should be selected.