The bisphenol A and epoxy derivatives in metal can inwall coating, as object of research, were studied on its determination method, migration regulation and process optimization. A high performance liquid chromatography with fluorescence detection method was carried out to investigate the migration of BFDGE, BADGE and their hydrolysis derivatives，and then this method was applied to process optimization. The optimum conditions were: baking temperature at 190℃, coating thickness of 11 g/m2, baking time of 12 min. Under these conditions, the residual volume of BFDGE, BADGE, BADEG·2H2O, BFDEG·2H2O were minimum, and of 0.066 μg/mL, 0.047 μg/mL, 0.092 μg/mL, 0.071 μg/mL, respectively.