In view of a full utilization of the aerodynamic performance of coaxial twin rotors and a reduction of unnecessary power losses, based on XFlow software, a simulation analysis has thus been conducted on the wing profile, angle of attack, and number of blades of coaxial rotor unmanned aerial vehicles. On the basis of the initial design and analysis, the aerodynamic optimization design of the drone is carried out by controlling variables to modify and control the number, shape, angle, and length of the rotor blades, so as to achieve a satisfactory lift. The research results show that the 8-16 blade hybrid optimization scheme can effectively reduce the mutual influence between the upper and lower rotors. The optimized model has increased lift by 18.54%, torque by 9.60%, and power by 17.67% compared to the initial model. All the aerodynamic characteristics of the optimized model have reached a relatively ideal state, with an more evident optimization effect.