A quantitative evaluation method for velocity uniformity coefficient has been proposed to address the issues of high pressure loss, uneven outlet wind speed, and low efficiency of commonly used CFD optimization simulation methods in automotive air conditioning ducts. And grid deformation parameters are created at the locations of pipelines with severe airflow separation, thus forming an integrated optimization method based on Isight integrated Sculptor grid deformation and STAR-CCM+ technology so as to achieve an automatic optimization of air conditioning ducts. The comparative analysis results show that by using the uniformity coefficient of air outlet velocity and automatic optimization technology, the pressure loss in the air duct is reduced by 26% to 34%, and the uniformity coefficient of air outlet velocity is increased by 16% to 33%, with the optimization efficiency significantly improved and the air outlet airflow remaining unchanged.