An analysis has been made of the hexagonal honeycomb fasting sandwich sheet covers by using ANSYS finite element structural analysis software. On the basis of the size effect of grid division in the hexagonal honeycomb hollow sandwich panel floor, a comparative study has been carried out on the effect relationship between the grid size of the fasting sandwich covers and the bearing capacity of the building covers, with the results showing that there is an obvious grid size effect of the regular hexagonal honeycomb fasting sandwich plate, and the steel concrete interaction is more sufficient with more excellent economic benefits. A further analysis has been made of the influence of concrete surface slab thickness on the grid size effect of this structure, with the results showing that an increase of the thickness of concrete surface slab has a positive gain on the bearing capacity of the building cover with a great influence on the grid size effect of the structure.