As an important component of sci-tech periodicals, the general sci-tech periodicals in universities provide the basic guarantee for cultivating the world-class sci-tech periodicals in our country with their irreplaceable value. Taking Packaging Journal as an example, based on an analysis of the current situations, it is found that there exist such problems as high dependence on the sponsoring unit, insufficient high-quality manuscript sources, and low influence index. Aiming at a solution of these problems, such development strategies have been proposed as serving professional talents, striving for high-quality manuscript sources, focusing on industry hotspots, continuously planning characteristic columns, reinforcing new media construction, innovating communication channels, as well as implementing cluster development and intense publication. Under the background of cultivating world-class sci-tech periodicals, it is advisable that the general sci-tech periodicals in universities should find their own value in the difficult situation, analyze the problems objectively, and innovate their publishing thinking when confronted with difficulties.