Based on the multi-level and multi-dimensional nature of industrial economic theory, a composite system integration degree model of advanced manufacturing industry and modern logistics industry is constructed by adopting the coordination theory, with an empirical study to be conducted based on the panel data of the development of advanced manufacturing industry and modern logistics industry in Guangdong province from 2011 to 2019. The empirical results show that the integrated development level of advanced manufacturing industry and modern logistics industry in Guangdong Province shows an upward trend, from weak integration level to moderate integration level, with the degree of development still not high. Among them, the order degree of the subsystem of advanced manufacturing industry and the subsystem of modern logistics industry rises alternately, with the advanced manufacturing industry being the main driving force of the integration degree of the composite system. Therefore, it is suggested to optimize the industrial layout, integrate industrial resources and promote the cooperation of the exchange platform, thus effectively promoting the integrated development of advanced manufacturing industry and modern logistics industry.