For an investigation of the flow characteristics of solid-liquid flows with HTAB, with stainless steel pipe with a diameter of 10 mm used as the experimental pipe, a research has thus been conducted on the main factors affecting the resistance characteristics of solid-liquid flows. The experimental results show that solid mass concentration and solid particle size are the main factors which affect the resistance characteristics of solid-liquid flows. By changing the solid mass concentration and particle size, the effects of surfactant on drag reduction characteristics of solid-liquid flows can be observed. It is found that the friction coefficient increases positively with that of the solid mass fraction under the same surfactant mass fraction and particle size. Meanwhile, the friction resistance coefficient increases positively with that of the particle size under the same surfactant mass fraction and solid mass concentration.