Based on a case study of the engineering example Tongxi Road Landscape Bridge of Dawangshan tourist resort in Changsha, Hunan Province, a calculation and analysis have been made of the stress of asymmetric curve continuous rigid frame bridge at different construction stages by using the finite element software Midas/civil, thus obtaining the stress variation law of asymmetric curve continuous rigid frame bridge at different construction stages. The results show that at the symmetrical construction stage, the compressive stress of the top and bottom plates of box girder in each section shows an overall upward trend; at the asymmetric construction stage, the compressive stress of the top plate of the box girder decreases as the cantilever length increases, while the stress of the bottom plate of the box girder increases with the increase of the cantilever length, with the section stress of the closure section increasing by 2 ~ 4 times after the completion of the prestressing tendon tensioning. The relative increase value of the compressive stress in the top plate of the section from the pouring of the previous beam segment to the pouring and tensioning of the next beam segment vibrates within a certain stress range with the increase of the number of beam segments; the relative decrease of the section roof stress from the previous beam section after the tensioning to the next beam segment before the tensioning changes in a certain stress range with the increase of the number of beam segments, while the cross-section floor stress changes show a downward trend.