In order to explore the influence of single-hole plugs on the resistance characteristics of the pipe flow of the surfactant drag reduction solution, the hole plugs with different aperture ratios and length-to-diameter ratios and different concentrations of drag reducer aqueous solutions are tested for local resistance loss under different working conditions, followed by a comparison between the resistance loss along the way and the corresponding results of pure water. The research results show that with the increase of the concentration of the drag reduction aqueous solution, the inflection point of the local drag coefficient of the cavern shifts backward. The larger the drag reduction Reynolds number range, the wider the continuous Reynolds number range of the local drag reduction. With the ratio of plug diameter to pipe diameter a constant, the local resistance tends to be larger when the plug length to pipe diameter is small, while the local resistance tends to be small when the plug length to pipe diameter ratio is large. With the length diameter ratio a constant, the local resistance decreases with the increase of the plug diameter ratio, and in the downstream of the plug, the redevelopment distance required for the drag reducing water solution to form a stable drag reduction flow decreases with the plug diameter ratio.