In view of such flaws in wired meter reading system as cable laying, cable exposure and poor anti-interference performance due to long communication lines, a design scheme of wireless intelligent water meter reading system has thus been proposed on the basis of LoRa communication technology of SX1278 chips, which facilitates the collection and remote management of the flow data of the intelligent water meters. An introduction has been made to the topology of the system network and the design of the system software and hardware, followed by a test and analysis of the system. The experimental results show that the system is functionally effective. The running test of the wireless meter reading system in several districts in Zhuzhou shows that the system has been successful with its expected design effects achieved.