In view of the characteristics of a newly-built 110 kV substation, proposed a 35 kV and 10 kV environmental-friendly gas-insulated switchgear. From three aspects of switchgear technical characteristics, collocation scheme and economic technology, analyzed the merits and demerits of the environmental-friendly gas-insulated switchgear, conventional KYN series of air-insulated switchgear and SF6 gas-insulated switchgear. The analytic results showed that: compared with the conventional KYN series of air-insulated switchgear and SF6 gas-insulated switchgear, environmental-friendly gas-insulated switchgear has the advantages of environmental protection, stable operation, easy maintenance, small area and good economic returns, etc., more in line with the construction requirement of the newly-built 110 kV substation.