Based on the situation of agricultural random supply and demand, and considering the income of product residual and the cost of stock losses, the coordination process of two-level supply chain composed of suppliers and vendors is studied. Through the analysis of profits of decentralized decision and centralized decision, the coordination model of agricultural supply chain profit-sharing contract is designed, and under the reasonable profit distribution coefficient, the supply chain can achieve optimal. An example analysis verifies the scientific and effective of the model.