In order to enhance the dispersion of silver doped nano-TiO2 antibacterial powder in Pro-oily polymer, silane coupling agent (KH570), maleic anhydride, trioctyl phosphate and butyl p-hydroxybenzoate were used to modify the surface of silver doped nano-TiO2. By means of X-ray diffraction (XRD), X-ray photoelectron spectrum (XPS) and scanning electronic microscope (SEM), the morphology and composition of antibacterial powder were characterized, and the antibacterial property of powder was tested with escherichia coli and fungi. The results indicate that: silver doped nano-TiO2 powder presents spherical distribution and elemental Ag attaches to the TiO2 surface. The silver doped nano-TiO2 powder modifyed by 3% silane coupling agent (KH570) at 30℃ distributes in paraffin and the interface, which shows excellent Lipophilic property, and antibacterial property of the modified powder is basically unchanged.