Nano spheric mesoporous silica sol is synthesized under the conditions of room temperature and different ph values. It is found that the best production technology is pH=4. With CTAB as a template, the hybrid mesoporous silica sol is prepared by cohydrolysising of TEOS and GPTMS at pH=4. The synthesized materials are characterized by XRD，TEM and Zetasizer Nano. The result indicates that the prepared mesoporous silica sol has good mesostructure and good dispersion with particle size about 25 nm.