Studies the influence of exogenous rrIL-6 on the modeling success ratio of type II diabetes rats and discusses the effects of different modeling means on DM rat FBG, serum IL-6 and FINS. SD rats are divided into two groups which are fed for 6 weeks with the hyper-lipid feedstuff and experience the 12 hours’ fasting. The first group experiences a one-time injection of STZ. STZ and rrIL-6 are injected into the second group. The result shows that the injection of exogenous IL-6 will reduce modeling success ratio to some extend. FBG of DM rats is increased remarkably by various modeling which has a little effect on DM rats’insulin secretion. After STZ injecting, the index of rats serum IL-6 increases significantly but varies little from exogenous IL-6 modeling.