According to requirements of not only high strength and hardness but also a certain toughness and good weldability of wear-resistant steel plate, the chemical composition of quenched and tempered HB400 wear-resistant steel is designed and the smelting and rolling processes are determined. The results show that the average Brinell hardness of high strength wear-resistant steel HB400 plate reaches 400HBW and has very good cold bending and weldability performance after being quenched and tempered. The indicators meet the design requirements.