Based on the technology-organization-environment (TOE) framework, this study constructs an integrated analytical framework for the development of the cultural tourism industry. With nine antecedent variables selected and 41 cities in the Yangtze River Delta region as research samples, the study, using NCA and QCA methods, conducts a configuration analysis on the development of the cultural tourism industry. The results show that no single factor constitutes a necessary condition for the high-level development of the cultural tourism industry; rather, the synergistic matching of multiple factors helps promote high-quality development. There are four driving paths for the high-level development of the cultural tourism industry, among which the organization-technology driven path plays a more prominent role. There is a potential substitution relationship between conditions, and consumption demand, urban green environment, transportation convenience, urbanization level, and human capital level can promote the development of the cultural tourism industry through equivalent substitution. The scale of cultural tourism resources and facilities and cultural tourism consumption demand are the core conditions for the non-high-level development, indicating that the development of the cultural tourism industry needs to improve the compatibility between supply and demand.