Taking the logistics industry in the Yangtze River Economic Belt as the research object, this paper calculates the comprehensive index of high-quality development of the logistics industry in the Yangtze River Economic Belt from 2010 to 2021 by the adopting entropy method. It uses the Dagum Gini coefficient and the Kernel density estimation to analyze the regional differences. The results show that the high-quality development of the logistics industry in the Yangtze River Economic Belt has been improving greatly. However, the regional differences are still obvious, with the downstream logistics industry presenting a higher-quality development while the middle and upper reaches of the logistics industry show a lower-quality development. But it may be a great thing to see the narrowing gap. Specifically, the economic development foundation, logistics carrying capacity and technological innovation capability show a downward trend in general, while the logistics industry performance shows an upward trend with stablegreen development. Therefore, it is suggested to strengthen regional cooperation of logistics industry in the Yangtze River Economic Belt and to narrow regional gaps. Besides, more attention should be paid to the technology innovation in logistics industry and infrastructure construction so as to improve the efficiency of logistics and transportation. Moreover, great efforts should be made to develop green logistics and to build a regional green logistics network for better recycling and utilization rate of materials.