The occurence of gene-edited baby case shows the necessity of regulating the misuse of germline editing technology through the intervention of criminal law.The human clinical application of germline editing technology includes three risks: safety risk, social management disorder risk and ethical risk. In the face of these risks, the criminal law should prohibit the clinical application of human germline editing that infringes on personal life and health, selectively regulate the application of human germline editing that endangers the order of social management, and respond cautiously to the ethical issues involved in germline gene editing technology. In order to cope with the challenges brought by gene editing technology, the criminal law should, while taking into account the modest and restraining nature, design related crimes to crack down on criminal acts.