Sci-tech innovation promotes the prosperity of cultural industry, and cultural industry also promotes the development of sci-tech innovation.The deep integration of the two has given birth to new industrial forms. Using the grey correlation analysis method, this article takes the data from 2008 to 2017 as an example for empirical analysis, and measures the grey correlation degree between sci-tech innovation and cultural industry. The results show that the interaction between sci-tech innovation and cultural industryis significantly improved, and the integrated development trend has been presented, however the integration of some elements has not yet met the development needs. Therefore, it is necessary to optimize the policy environment for the deep integration of technological innovation and cultural industry, increase the value of sci-tech innovation in the cultural industry development, increase the effective supply of innovative talents in the cultural industry, strengthen the market development of cultural resources in the integrated development,to promote the positive interaction between technological innovation and cultural industry to achieve integrated development.