In order to study the influence of spray printing process parameters on the printing quality of coated copperplate paper in waterborne ink-jet printing process, the positive and negative correlation between the specific quality evaluation index and the spray printing process parameters was analyzed. By changing the key process parameters of nozzle voltage, ignition frequency and pulse width in inkjet printing, and measuring the four key quality indicators of printed matter, namely, field density, color difference, brightness and gloss, the positive and negative correlation of each process parameter to the specific quality indicators of printed matter was qualitatively analyzed. Then, statistical analysis method was used to study the influence of printing process parameters on printing effect. Finally, partial least square regression method was used to establish the corresponding regression model. The results showed that the pulse width had a great influence on the field density, color difference, glossiness and brightness of coated paper prints, and the ignition frequency and voltage had a relatively small influence on the field density, color difference, printing glossiness and brightness of coated paper prints in a certain range. Therefore, in the process of water-based ink-jet printing of coated paper, the quality of the printed matter can be improved by reasonably controlling the key parameters of the printing process. The partial least square regression prediction model had a good prediction ability for the color difference and lightness of the printed matter.