Reviewing the sixty years’ development of the theory of syntax-semantics interface in generative grammar, the mainstream generative grammar firstly ignores the semantics, and then the syntax-semantics interface undergoes the development from the earliest T-markers to deep structure, and then to surface and deep structure, to logical form, and finally to the conceptual-intentional interface. Alternative generative theories abolish the transformation operation, regard the surface structure as the only syntactic structure, and combine the syntactic analysis and semantic explanation together. The differences of syntax-semantics interface in mainstream generative grammar and alternative generative theories are mainly reflected in the opposition of multiple layers and single layer, uni-directionality and bi-directionality as well as uniformity and flexibility. The future research should be centered on grasping the latest development trend of the theory, drawing on the merits of different theories, strengthening the practice of the theory and improving the explanatory power of theory.