The rule of law is key to regional governance. The legal safeguard mechanism of Chang Zhu Tan area is derived from market failure theory and government anomie theory. In view of the problems existing in the present legal mechanism such as the reinforcement of executive power level operation,the lack of corresponding laws and regulations, the conflict between some laws and regulations and the imperfectness of law culture cultivation mechanism, this paper puts forward that in order to innovate the legal safeguard mechanism of Chang Zhu Tan area, the construction mechanism of laws and regulations should be strengthened, the legislation coordination mechanism perfected, the strict law enforcement mechanism consolidated,the justice mechanism adhered and the service and construction mechanism of the law based government accelerated.