The Diplomacy Department of Central Political School was founded in 1930. The basic framework of the curriculum of the Diplomacy Department was established under the leadership of the dean of studies Luo Jialun and the dean of department Xu Mo. With the change of the current political situation, the curriculum experienced a series of adjustment and enrichment. The teaching and extracurricular activities of the Diplomacy Department interacted with each other frequently, and formed a mechanism of diplomatic talent cultivation with the curriculum as the basis, teaching as the main body, and extracurricular activities as the supplement. Through examining the curriculum design and teaching operation of the Diplomacy studies of the Central Political School, we can know more about the disciplinization process of the Diplomacy Studies of the Republic of China.