The fifth war zone of National Revolutionary Army was founded in July 1937, and it has participated in the battle in Xuzhou, Wuhan, Suizhou-Zaoyang and Zaoyang-Yichang, etc. It shouldered an important combat mission, clamped and annihilated a lot of Japanese troops, and had an important strategic role. Though this role was weakened later, it was still an important part of Chinese war zone. Its relationship with other war zones gradually changed from “leading” to “cooperation”. Constituted as a unified whole, the fifth war zone had many important strategic collaboration and cooperation with other war zones. In order to defend the national survival, the fifth war zone has made prominent contribution both in annihilating enemies and reducing losses.