Since China's reform and opening up, Guizhou has accumulated rich experience in the construction of a harmonious ethnic relations: improving the party's ethnic policies; promoting the economic development; expanding ethnic interests appeal channel; cultivating the shared culture; perfecting the system of regional ethnic autonomy. To further promote harmonious ethnic relations in Guizhou, we must be alert to the interference of extreme nationalism, dispel the negative effect in the national culture infiltration and integration process, promote the coordinated development of economy and society between ethnic minority areas and other regions, prevent and surpress the local protectionism.