Mao Zedong’s theory of practice is a milestone of the development of epistemology in Chinese history of philosophy. Based on its critical inheritance and carrying forward of the traditional philosophy，it also imprints the characteristics of Wang Chuanshan’s historical philosophy，such as the social ontology，social exchange theory and practical rationalism. There is also certain origin relation between the formation of Mao Zedong’s early ideal personality and Wang Chuanshan’s historical philosophy. The application of Mao Zedong’s practice theory is of vital importance in Chinese revolution and adopting the specific methods.