Heavy metals in packaging materials can migrate to food and the environment. To address this issue，lactic acid bacteria were isolated from health food and fermented yoghurt. The main experimental strains include Bifidobacterium, Lactobacillus plantarum, Lactobacillus acidophilus and Leuconostoc mesenteroides, etc., which were used in the adsorption experiments of heavy metals. Among a diverse array of experimental strains, Lactobacillus plantarum 121 was successfully isolated. This particular strain demonstrated a relatively outstanding capacity for heavy metal adsorption. By measuring the growth curve of Lactobacillus plantarum 121, it was determined that Lactobacillus plantarum 121 is in logarithmic phase within 6 h, and the thallus cells in logarithmic phase were collected for experiments. The Lactobacillus plantarum 121 was inactivated by high temperature sterilization and pasteurization respectively, and the comparison with the inactivation of Lactobacillus plantarum 121 shows that the inactivation of Lactobacillus plantarum 121 has the best removal effect on lead. The adsorption behavior of this strain towards heavy metals shows considerable promise in the fields of green packaging and environmental governance.