Aiming at the problems such as low utilization rate of existing packaging space, waste of materials and lack of novelty, according to the research results of foldable packaging, Miura folding, diagonal folding and Yoshimura folding were adopted to construct the corresponding mathematical model of folding, and optimize the parameters of folding structure to carry out the variable volume design of packaging structure. The experimental results show that all of the three folding packaging structures have good folding ratio, while the support strength and tensile strength test can meet the application requirement by effectively protecting the contents and being easy to transport and storage. Among them, the comprehensive effect of diagonal folding packaging is the best. With its practicability and market prospects, it can provide a new idea for the collapsible variable volume packaging structure design.