Aiming at the problem of the poor compatibility of the interface between conventional conductive filler and hydrogel matrix, the flexible liquid metal (LM) was embedded in a hydrogel network formed by copolymerization of [2-(methylacryloxy) ethyl] dimethyl -(3-propyl sulfonate) ammonium hydroxide (SBMA) and N-(2-hydroxyethyl) acrylamide (HEAA). A class of LM/p(SBMA-co-HEAA) conductive hydrogels with super-stretchability, high adhesion and excellent sensing capability were constructed. The results show that the surface of LM nanoparticles formed by ultrasonic dispersion had a rich structure of hydroxyl gallium oxide, which was easy to cause hydrogen bond interaction with the hydroxyl group in HEAA, and improved the stability of the interface between the conductive filler and the hydrogel matrix. In addition, the strain sensor based on the conductive hydrogel could maintain stable sensing performance under the condition of small strain 1% or large strain 150%, indicating that the strain sensor has broad application prospects in the field of human motion detection and intelligent packaging.