荧光磁性纳米粒子合成及其性能
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TB34

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国家自然科学基金国家重大科研仪器研制项目(51927810);湖南省教育厅科学研究基金资助项目(24A0412)


Synthesis and Properties of Fluorescent Magnetic Nanoparticles
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    摘要:

    为实现纳米粒子的荧光磁性双功能化,设计并合成一种强荧光超顺磁性的双功能复合材料。将罗丹明B(RhB)染色剂与聚乙二醇(PEG)共价偶联,然后通过氢键作用将聚乙二醇-罗丹明B(PEG-RhB)键合到Fe3O4表面。PEG的存在可以形成有效的空间屏障,不仅减缓了Fe3O4纳米粒子由于磁偶极相互作用而导致的团聚现象,还减少了RhB直接与磁性粒子表面接触。此外,该粒子的成功制备可以实现磁场-重力场耦合下实时观测磁性纳米粒子的链结构。Fe3O4-PEG-RhB在靶向治疗、荧光标记和磁流体密封等方面有着巨大的应用潜力。

    Abstract:

    In order to realize the fluorescence magnetic bifunctionalization of nanoparticles, a bifunctional composite material with high fluorescence superparamagnetism was successfully designed. The rhodamine B (RhB) dye was covalently coupled with polyethylene glycol (PEG), and then the polyethylene glycol-rhodamine B (PEG-RhB) was successfully bonded to the surface of the ferric oxide (Fe3O4) through the hydrogen bonding. An effective space barrier was established due to the presence of PEG, which not only prevented the agglomeration of Fe3O4 nanoparticles through the magnetic dipole interaction, but also reduced the direct contact between RhB and the surface of magnetic particles. Moreover, the chain structure of magnetic nanoparticles can be observed in real time under the condition of magnetic field-gravity field coupling, which has great application potential in targeted therapy, fluorescence labeling and magnetic fluid seal and so on.

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仝婧婧,谢 涛,李祥刚,郑虹丽,殷倩妹,冯 妍.荧光磁性纳米粒子合成及其性能[J].包装学报,2025,17(2):69-77.

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  • 在线发布日期: 2025-04-03
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