In response to the low efficiency in the courier delivery industry, a guided roller courier sorting system is designed to achieve intelligent and rapid sorting of courier parcels through the cooperation of the flipping structure and the guided roller sorter. SolidWorks software is used to model the scanning device, the upper package area, the flip structure, the sorting wheel structure and the overall structure of the courier transportation in three dimensions. Modal analysis of the sorting wheel frame is carried out using ANSYS Workbench, and it shows that the thickness of the support legs should be increased to ensure their stiffness. The optimal design of response surface based on DesignXplorer module can increase the overall stiffness of the tilting structure and reduce the total mass of the structure. After optimization, the total mass is reduced by 9.42%, which has obvious lightweight effect, and the strength and stiffness can meet the calibration conditions. The system is highly scalable and the number of sorters can be flexibly configured according to the sorting requirements. It can meet the needs of small and medium-sized courier companies for sorting logistics and distribution goods, and has a broad market prospect and great promotion value.