An overview of the current research was provided on multi-material manufacturing of titanium/steel and the application of additive manufacturing (AM) technologies in this domain by reviewing the isolation effects of various interlayers on the reactive alloy components at the titanium/steel interface and examining the potential of medium and high-entropy alloys as interlayer materials. Through the analysis of microstructure and mechanical properties of the titanium/steel interface, the formation mechanisms of various intermetallic compounds in the transition zone were systematically discussed, while the impacts of process parameters and structural design on defect formation and elemental diffusion behavior at the multi-material interface were also investigated. The application of AM techniques in titanium/steel multi-material connections aims to provide insights for achieving defect-free, strong, and solidly bonded interfaces, and promotes the development of the packaging industry in a more efficient, environmentally friendly and intelligent direction.