The printing quality of QR code directly affects the accuracy of barcode information transmission. In order to analyze the main factors affecting the printing quality of QR code, a QR code image acquisition platform was developed based on the national standards for QR code inspection. Through making QR code test samples, the influences of grayscale changes and geometric changes on the printing quality parameters of the QR code were analyzed, such as symbol contrast, modulation ratio, axial inconsistency, grid inconsistency, etc. The experimental results obtained the image quality requirements of different QR code quality parameters grading, and provided a reference for the printing quality inspection and control of the QR code.