Based on the extended producer responsibility (EPR), a supply chain optimization decision-making model is established from two factors of recyclability and durability in packaging design. Two modes of packaging are studied and compared, one is that packaging manufacturers only provide general express packaging or only provide recyclable express packaging. The results show that with the improvement in packaging recovery rate, packaging manufacturers will improve the recyclability of express packaging, while the durability of recyclable express packaging needs to take into consideration of the relationship between durability and recyclability. When durability and recyclability are synergistic, durability will rise accordingly, while durability will decline when durability and recyclability conflict with each other. When only producing recyclable express packaging, the profit of packaging manufacturers and social welfare are always higher than those when only producing general express packaging, but the incentive for packaging collection for packaging manufacturers is lower than that when only producing general express packaging.