In order to better apply the natural active ingredients of plants to skin care formula, taking three single factors of thickener dosage, emulsification temperature and rosemary extract concentration as independent variables, with the comprehensive score of applying feeling as the dependent variable, the process formula optimization of rosemary extract hand cream was carried out by response surface optimization experiment, and the prepared product was evaluated by indicators such as the sensory evaluation, heat and cold resistance and irritation. The results showed that the optimal process conditions were as follows: the quality score of rosemary extract 75%, the amount of thickener 0.20 g, and the emulsification temperature 80 ℃. The rosemary hand cream prepared under this condition had a uniform color, a refreshing and moist texture. With the pH value of 5.85, it was well received by consumers because of good cold and heat resistance and stability, without irritating reaction. The optimized preparation process provided a certain theoretical reference for the research of rosemary extract in the skin care industry.