Aiming at the problems of dust pollution and low conveying efficiency in the screw conveying process of powder materials, in order to achieve the effect of degassing and dense conveying of powder materials, the method of powder conveying dense screw combined with micro negative pressure vacuum chamber was adopted, and the dense section of the screw feeding device was designed for structure with parameter optimization. By establishing a three-dimensional model of the spiral feeding device and selecting genetic algorithm for parameter optimization, combined with EDEM-Fluent coupling simulation, the compacting effect of the designed device was analyzed. The results showed that the average mass flow rate of the material was about 0.831 kg/s, the maximum conveying density was 889.299 kg/m3, the maximum density percentage was 20.51%, the mass flow rate fluctuated within the range of 0.783~0.883 kg/s, the fluctuation percentage was within ±6.26%, it had a good compacting degassing effect. While ensuring the increase in material mass flow, it reduced flow fluctuations and improved feeding accuracy.