The curdlan-based packaging film was taken as the representative of bio-based packaging material, dimethyl phthalate (DMP), di-n-butyl phthalate (DBP) and di (2-ethylhexyl phthalate) (DEHP) were selected as the research objects. The migration of plasticizer was determined by gas chromatography-mass spectrometry (GC-MS). The migration into n-hexane, 50% ethanol, 4% acetic acid and distilled water food simulants from curdlan-based films with plasticizer mass fraction of 0.1%, 0.5%, 1% and 3% were studied at low temperature (4 ℃), normal temperature (25 ℃) and high temperature (40 ℃). The migration models of three kinds of plasticizers in n-hexane were established by using Weibull distribution function. The results showed that the migration amount of the three plasticizers in the four food simulants was in the descending order: n-hexane, 50% ethanol, 4% acetic acid, water. With the extension of time, the migration of plasticizer increased gradually at first, the balance was reached on the third day to the maximum. With the increase of temperature, the migration of plasticizer increased, and the larger the initial amount was, the greater the migration. The three plasticizers were more likely to migrate in n-hexane and should avoid contacting with oily food in practical application. The Weibull migration model of DMP, DBP and DEHP based on three parameters of Cm, τ and β was established with certain predictability and could be used to quickly predict the migration amount of phthalate plasticizers.