Aiming at the conditions of logistics products in the process of transportation and the issues of estimating the fatigue life of the products, two common fatigue life prediction methods were listed according to the current damage evaluation criteria and classical damage theory. The effectiveness of the two methods was verified by examples from theoretical analysis and Matlab Simulink numerical simulation analysis, and the predicted fatigue life from the two methods was basically the same. By estimating the fatigue life of the product, it could provide reference for the transportation mode, transportation timing and transportation buffer packaging design of the product.