CuMOF-x(x=1, 2, 3) was obtained by hydrothermal method and calcination under inert atmosphere with cupric nitrate pentahydrate, terephthalic acid, 2-aminopyrimine and ketjenblack 600 as raw materials. The effects of terephthalic acid, 2-aminopyrimidine and binary hybrid ligand on the catalytic properties of the products were deeply studied. The catalytic performance of oxygen reduction （ORR）as-prepared catalysts was measured by linear scanning voltammetry using electrochemical workstation, and the electron transfer numbers of oxygen reductions were calculated by Koutecky-Levich equation. The result showed that 2-aminopyrimidine nitrogen-containing ligand had better effect than that of terephthalic acid ligand on the catalytic performance for ORR, and the binary mixed ligand of the two had the best effect. The as prepared three catalysts CuMOF-x(x=1, 2, 3) all catalyzed oxygen reduction reaction through a 4e- pathway.