In view of some defects in current packaging and structure of hypotensive drugs for middle-aged and old people in China, the problems in the packaging of drugs were analyzed, such as no obvious contrast in color, non-compliance with ergonomics in structure design, etc. based on the analysis of patients’psychological and physiological needs through using the methods of questionnaire survey, eye movement experiment and behavior experiment, by applying the interactive design theory , psychology of the elderly, packaging science, integrating sensory factors to attract the attention of consumers, and following the concept of people-orientation, the interactive packaging design for drug repositioning was carried out in order to effectively solve the problem of medication inconvenience for elderly patients and meet the needs of patients at the physiological and psychological levels.