In order to keep the ice cream within a reasonable temperature range in the distribution of the “last mile”, a thermal insulation packaging based on 3D printing technology was developed. The effects of container wall thickness, external temperature and humidity conditions on the thermal insulation performance were analyzed, and the 3D surface model and equation of external temperature, thickness and thermal insulation time were also established, with the verification on three packaging models of different temperature and thickness. The results showed that 30 mm thickness could meet the requirement of 60 min delivery time for ice cream. With the external temperature and humidity being 23 ℃/50%RH, 30 ℃/85%RH, the overall insulation time of the three test points could be satisfied. At 40℃/90% RH, only the center point could meet the delivery requirement of insulation time. The error between theoretical and experimental value was within 10%, and the surface equation had certain reference value.