Product packaging not in conformity with the principles of human factors often causes many issues in use process such as difficulties in opening, picking and placing and leads to potential security hazards. In order to provide safe and convenient packaging, biomechanical analysis and behavior simulation analysis were put in the packaging design and production process by using human factor principles. The researches on packaging based on human factors are mainly embodied in two aspects: First, the study of human factors in the process of packaging products, including hand biomechanics, visual activity and human body size; Second, the study of human factors in the process of packaging production, including the influence of workers’ operation posture on workers’ health and work efficiency in the packaging production lines, the influence of equipment visual recognition such as interface design and color on human-computer interaction, the influence of the noise, light and temperature in the works on workers’ operational capacity, and the influence of the production management system as a man-machine system on the economic efficiency of enterprises and social benefits.