Novel hydroxyethyl cellulose/chitosan(HEC/CS) blend coating was prepared by using HEC and CS as raw materials, and the blend coating was used for the preservation of blueberries. Effects of the blend coating on the quality safety of blueberries were investigated during storage time at room temperature by using pure CS coating treated bluebe-rries and untreated blueberries as controls. Results showed that HEC/CS blending coating could reduce the weight loss and rotting rate of blueberries. Furthermore, blueberries treated with the blending coating presented the minimum changes in total soluble solids, Vc and anthocyanin contents.