Combined with production practice, the influence of grain direction on printing quality was discussed in the process of carton printing production, gold blocking, coating, oil glazing, laminating, gold blocking, laser stamping transfer and die-indentation. The problems such as misregistration, wrinkle, out of stamping, horizontal burst line, bonding lax between outside and inside paper, obvious shaping error and poor opening were analyzed in detail. Some viable solutions were proposed to effectively solve production problems and save costs.