There existing some problems in corrugated cardboard producing enterprises, such as the softening, slow drying and poor cohesion in rainy season and humid climate. Cassava starch was prepared as the raw material, while potassium monopersulfate was used as oxidant, with composite fillers and melamine formaldehyde resin added into it. A quick-drying, water resistant oxidized starch adhesive was prepared via cold method. Through the modification test, when the added material in starch is equivalent to the quality of 0.3% of potassium monopersulfate, 5% of the composite fillers, 4% of melamine formaldehyde resin, the performance of the starch adhesive proved better. And the result showed that with the potassium monopersulfate as oxidiant, it could not only make up for the normal oxidant deficiencies, but also shorten the adhesive production cycle. After the modification of composite fillers and melamine formaldehyde resin, the bonding strength, edgewise crush resistance, drying rate of starch adhesive and adhesive water resistance of the corrugated cardboard were improved, with the production cost of adhesive reduced as well.