Abstract:In order to meet the various needs of trauma treatment, there is an urgent need to develop multifunctional wound dressings with toughness, ductility, self-adhesiveness, biocompatibility and antimicrobial properties to promote the cicatrisation and regeneration of damaged tissue. Based on the chemical crosslinking strategy, a kind of polysaccharide-based NIR light-responsive antibacterial hydrogels (QCMCS/ODex-DA/TP/PDA,QOTP) consisting of tea polyphenols (TP), polydopamine nanoparticles (PDA NPs), quaternary ammonium carboxymethyl chitosan (QCMCS) and dopamine-decorated oxidized dextran (ODex-DA) was prepared. The abundant catechol groups gave QOTP hydrogels good adhesion, showing firm adhesion to organ tissues (heart, liver, stomach, and muscle tissue) both in air and underwater. In addition, the synergistic antibacterial effect between QCMCS and PDA NPs made QOTP hydrogels highly effective in bactericidal properties under near-infrared (NIR) irradiation (antibacterial rate against S. aureus and E. coli was higher than 99%). These light-responsive hydrogels with double synergistic antibacterial effect would have great potential application in clinical trauma treatment.